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Mcm10 plays an essential role in origin DNA unwinding after loading of the CMG components
The CMG complex composed of Mcm2-7, Cdc45 and GINS is postulated to be the eukaryotic replicative DNA helicase, whose activation requires sequential recruitment of replication proteins onto Mcm2-7. Current models suggest that Mcm10 is involved in assembly of the CMG complex, and in tethering of DNA...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3343466/ https://ncbi.nlm.nih.gov/pubmed/22433840 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2012.68 |
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