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Trans-dominant inhibition of transcription activator LFB1.
Liver-enriched factor LFB1 (also named HNF1) is a dimeric transcription activator which is essential for the expression of many hepatocyte-specific genes. Here we demonstrate that LFB1 mutants in the POU A-like or in the homeo domains inhibit wild-type DNA binding by forming inactive heterodimeric c...
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| Auteurs principaux: | , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
1992
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| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC334337/ https://ncbi.nlm.nih.gov/pubmed/1331985 |
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