JNK regulates the photic response of the mammalian circadian clock

The posttranslational regulation of mammalian clock proteins has been assigned a time-keeping function, but seems to have more essential roles. Here we show that c-Jun N-terminal kinase (JNK), identified by inhibitor screening of BMAL1 phosphorylation at Ser 520/Thr 527/Ser 592, confers dynamic regu...

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Hlavní autoři: Yoshitane, Hikari, Honma, Sato, Imamura, Kiyomichi, Nakajima, Hiroto, Nishide, Shin-ya, Ono, Daisuke, Kiyota, Hiroshi, Shinozaki, Naoya, Matsuki, Hirokazu, Wada, Naoya, Doi, Hirofumi, Hamada, Toshiyuki, Honma, Ken-ichi, Fukada, Yoshitaka
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2012
Témata:
Scientific Reports
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3343351/
https://ncbi.nlm.nih.gov/pubmed/22441692
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/embor.2012.37
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