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Roles of CLOCK Phosphorylation in Suppression of E-Box-Dependent Transcription

In mammalian circadian clockwork, the CLOCK-BMAL1 heterodimer activates E-box-dependent transcription, while its activity is suppressed by circadian binding with negative regulators, such as CRYs. Here, we found that the CLOCK protein is kept mostly in the phosphorylated form throughout the day and...

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Main Authors: Yoshitane, Hikari, Takao, Toshifumi, Satomi, Yoshinori, Du, Ngoc-Hien, Okano, Toshiyuki, Fukada, Yoshitaka
格式: Artigo
語言:Inglês
出版: American Society for Microbiology (ASM) 2009
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2698759/
https://ncbi.nlm.nih.gov/pubmed/19414601
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01864-08
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