Llwytho...

Roles of CLOCK Phosphorylation in Suppression of E-Box-Dependent Transcription

In mammalian circadian clockwork, the CLOCK-BMAL1 heterodimer activates E-box-dependent transcription, while its activity is suppressed by circadian binding with negative regulators, such as CRYs. Here, we found that the CLOCK protein is kept mostly in the phosphorylated form throughout the day and...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Yoshitane, Hikari, Takao, Toshifumi, Satomi, Yoshinori, Du, Ngoc-Hien, Okano, Toshiyuki, Fukada, Yoshitaka
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Microbiology (ASM) 2009
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2698759/
https://ncbi.nlm.nih.gov/pubmed/19414601
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01864-08
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