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Roles of CLOCK Phosphorylation in Suppression of E-Box-Dependent Transcription
In mammalian circadian clockwork, the CLOCK-BMAL1 heterodimer activates E-box-dependent transcription, while its activity is suppressed by circadian binding with negative regulators, such as CRYs. Here, we found that the CLOCK protein is kept mostly in the phosphorylated form throughout the day and...
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| Главные авторы: | , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
American Society for Microbiology (ASM)
2009
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2698759/ https://ncbi.nlm.nih.gov/pubmed/19414601 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01864-08 |
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