Organismal propagation in the absence of a functional telomerase pathway in Caenorhabditis elegans

To counteract replication-dependent telomere shortening most eukaryotic cells rely on the telomerase pathway, which is crucial for the maintenance of proliferative potential of germ and stem cell populations of multicellular organisms. Likewise, cancer cells usually engage the telomerase pathway for...

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Bibliographic Details
Main Authors: Lackner, Daniel H, Raices, Marcela, Maruyama, Hugo, Haggblom, Candy, Karlseder, Jan
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2012
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3343340/
https://ncbi.nlm.nih.gov/pubmed/22425786
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2012.61
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