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Mechanism for nucleic acid chaperone activity of HIV-1 nucleocapsid protein revealed by single molecule stretching

The nucleocapsid protein (NC) of HIV type 1 is a nucleic acid chaperone that facilitates the rearrangement of nucleic acids into conformations containing the maximum number of complementary base pairs. We use an optical tweezers instrument to stretch single DNA molecules from the helix to coil state...

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Main Authors: Williams, Mark C., Rouzina, Ioulia, Wenner, Jay R., Gorelick, Robert J., Musier-Forsyth, Karin, Bloomfield, Victor A.
Formáid: Artigo
Teanga:Inglês
Foilsithe: The National Academy of Sciences 2001
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Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC33432/
https://ncbi.nlm.nih.gov/pubmed/11344257
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.101033198
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