Human Cataract Mutations in EPHA2 SAM Domain Alter Receptor Stability and Function

The cellular and molecular mechanisms underlying the pathogenesis of cataracts leading to visual impairment remain poorly understood. In recent studies, several mutations in the cytoplasmic sterile-α-motif (SAM) domain of human EPHA2 on chromosome 1p36 have been associated with hereditary cataracts...

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Bibliografiske detaljer
Main Authors: Park, Jeong Eun, Son, Alexander I., Hua, Rui, Wang, Lianqing, Zhang, Xue, Zhou, Renping
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2012
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3343017/
https://ncbi.nlm.nih.gov/pubmed/22570727
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0036564
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