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Somatic mitochondrial DNA mutations in cancer escape purifying selection and high pathogenicity mutations lead to the oncocytic phenotype: pathogenicity analysis of reported somatic mtDNA mutations in tumors

BACKGROUND: The presence of somatic mitochondrial DNA (mtDNA) mutations in cancer cells has been interpreted in controversial ways, ranging from random neutral accumulation of mutations, to positive selection for high pathogenicity, or conversely to purifying selection against high pathogenicity var...

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Bibliografski detalji
Glavni autori: Pereira, Luísa, Soares, Pedro, Máximo, Valdemar, Samuels, David C
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2012
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3342922/
https://ncbi.nlm.nih.gov/pubmed/22299657
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-12-53
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