Comparing Phylogeny and the Predicted Pathogenicity of Protein Variations Reveals Equal Purifying Selection across the Global Human mtDNA Diversity

We used detailed phylogenetic trees for human mtDNA, combined with pathogenicity predictions for each amino acid change, to evaluate selection on mtDNA-encoded protein variants. Protein variants with high pathogenicity scores were significantly rarer in the older branches of the tree. Variants that...

Full description

Saved in:

Bibliographic Details
Main Authors:	Pereira, Luísa, Soares, Pedro, Radivojac, Predrag, Li, Biao, Samuels, David C.
Format:	Artigo
Language:	Inglês
Published:	Elsevier 2011
Subjects:	Article
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC3071914/ https://ncbi.nlm.nih.gov/pubmed/21457906 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajhg.2011.03.006
Tags:	Add Tag No Tags, Be the first to tag this record!

Comparing Phylogeny and the Predicted Pathogenicity of Protein Variations Reveals Equal Purifying Selection across the Global Human mtDNA Diversity

Similar Items