Methionine aminopeptidase 2 is required for HSC initiation and proliferation

In a chemical screening, we tested the antiangiogenic effects of fumagillin derivatives and identified fumagillin as an inhibitor of definitive hematopoiesis in zebrafish embryos. Fumagillin is known to target methionine aminopeptidase II (MetAP2), an enzyme whose function in hematopoiesis is unknow...

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Autori principali: Ma, Alvin C. H., Fung, Tsz K., Lin, Rachel H. C., Chung, Martin I. S., Yang, Dan, Ekker, Stephen C., Leung, Anskar Y. H.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Hematology 2011
Soggetti:
Hematopoiesis and Stem Cells
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3342862/
https://ncbi.nlm.nih.gov/pubmed/21937698
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-04-350173
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