Methionine aminopeptidase 2 is required for HSC initiation and proliferation

In a chemical screening, we tested the antiangiogenic effects of fumagillin derivatives and identified fumagillin as an inhibitor of definitive hematopoiesis in zebrafish embryos. Fumagillin is known to target methionine aminopeptidase II (MetAP2), an enzyme whose function in hematopoiesis is unknow...

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Autors principals: Ma, Alvin C. H., Fung, Tsz K., Lin, Rachel H. C., Chung, Martin I. S., Yang, Dan, Ekker, Stephen C., Leung, Anskar Y. H.
Format: Artigo
Idioma:Inglês
Publicat: American Society of Hematology 2011
Matèries:
Hematopoiesis and Stem Cells
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3342862/
https://ncbi.nlm.nih.gov/pubmed/21937698
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-04-350173
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