Point mutations in a nucleoside transporter gene from Leishmania donovani confer drug resistance and alter substrate selectivity
Leishmania parasites lack a purine biosynthetic pathway and depend on surface nucleoside and nucleobase transporters to provide them with host purines. Leishmania donovani possess two closely related genes that encode high affinity adenosine-pyrimidine nucleoside transporters LdNT1.1 and LdNT1.2 and...
Shranjeno v:
| izdano v: | Proc Natl Acad Sci U S A |
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| Principais autores: | , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
National Academy of Sciences
2001
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC33427/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11353834/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.101537298 |
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