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Point mutations in a nucleoside transporter gene from Leishmania donovani confer drug resistance and alter substrate selectivity

Leishmania parasites lack a purine biosynthetic pathway and depend on surface nucleoside and nucleobase transporters to provide them with host purines. Leishmania donovani possess two closely related genes that encode high affinity adenosine-pyrimidine nucleoside transporters LdNT1.1 and LdNT1.2 and...

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Detalhes bibliográficos
Main Authors: Vasudevan, Gayatri, Ullman, Buddy, Landfear, Scott M.
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 2001
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC33427/
https://ncbi.nlm.nih.gov/pubmed/11353834
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.101537298
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