Oxysterol Sulfation by SULT2B1b Suppresses LXR/SREBP-1c Signaling Pathway and Reduces Serum and Hepatic Lipids in Mouse Models of NAFLD

BACKGROUND: Cytosolic sulfotransferase (SULT2B1b) catalyzes oxysterol sulfation. 5-cholesten-3β-25-diol-3-sulfate (25HC3S), one product of this reaction, decreases intracellular lipids in vitro by suppressing LXR/SREBP-1c signaling, with regulatory properties opposite to those of its precursor 25-hy...

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Main Authors: Bai, Qianming, Zhang, Xin, Xu, Leyuan, Kakiyama, Genta, Heuman, Douglas, Sanyal, Arun, Pandak, William M., Yin, Lianhua, Xie, Wen, Ren, Shunlin
Format: Artigo
Jezik:Inglês
Izdano: 2012
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3342481/
https://ncbi.nlm.nih.gov/pubmed/22225954
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.metabol.2011.11.014
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