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Inhibiting oncogenic signaling by sorafenib activates PUMA via GSK3β and NF-κB to suppress tumor cell growth

Aberrant Ras/Raf/MEK/ERK signaling is one of the most prevalent oncogenic alterations and confers survival advantage to tumor cells. Inhibition of this pathway can effectively suppress tumor cell growth. For example, sorafenib, a multi-kinase inhibitor targeting c-Raf and other oncogenic kinases, ha...

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書目詳細資料
Main Authors: Dudgeon, Crissy, Peng, Rui, Wang, Peng, Sebastiani, Andrea, Yu, Jian, Zhang, Lin
格式: Artigo
語言:Inglês
出版: 2012
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3342476/
https://ncbi.nlm.nih.gov/pubmed/22286758
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2011.644
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