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Altered Composition of Liver Proteasome Assemblies Contributes to Enhanced Proteasome Activity in the Exceptionally Long-Lived Naked Mole-Rat

The longest-lived rodent, the naked mole-rat (Bathyergidae; Heterocephalus glaber), maintains robust health for at least 75% of its 32 year lifespan, suggesting that the decline in genomic integrity or protein homeostasis routinely observed during aging, is either attenuated or delayed in this extra...

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Main Authors: Rodriguez, Karl A., Edrey, Yael H., Osmulski, Pawel, Gaczynska, Maria, Buffenstein, Rochelle
פורמט: Artigo
שפה:Inglês
יצא לאור: Public Library of Science 2012
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3342291/
https://ncbi.nlm.nih.gov/pubmed/22567116
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0035890
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