A cytosolic protein factor from the naked mole-rat activates proteasomes of other species and protects these from inhibition

The naked mole-rat maintains robust proteostasis and high levels of proteasome-mediated proteolysis for most of its exceptional (~31y) life span. Here, we report that the highly active proteasome from the naked mole-rat liver resists attenuation by a diverse suite of proteasome-specific small molecu...

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Bibliografiske detaljer
Udgivet i:Biochim Biophys Acta
Main Authors: Rodriguez, Karl A., Osmulski, Pawel A., Pierce, Anson, Weintraub, Susan T., Gaczynska, Maria, Buffenstein, Rochelle
Format: Artigo
Sprog:Inglês
Udgivet: 2014
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4829350/
https://ncbi.nlm.nih.gov/pubmed/25018089
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbadis.2014.07.005
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