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In vivo efficacy of the histone deacetylase inhibitor suberoylanilide hydroxamic acid in combination with radiotherapy in a malignant rhabdoid tumor mouse model

PURPOSE: Histone deacetylase inhibitors are promising new substances in cancer therapy and have also been shown to sensitize different tumor cells to irradiation (XRT). We explored the effect as well as the radiosensitizing properties of suberoylanilide hydroxamic acid (SAHA) in vivo in a malignant...

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Autors principals: Thiemann, Markus, Oertel, Susanne, Ehemann, Volker, Weichert, Wilko, Stenzinger, Albrecht, Bischof, Marc, Weber, Klaus-J, Perez, Ramon Lopez, Haberkorn, Uwe, Kulozik, Andreas E, Debus, Jürgen, Huber, Peter E, Battmann, Claudia
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2012
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3342162/
https://ncbi.nlm.nih.gov/pubmed/22458853
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1748-717X-7-52
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