TLR9 Ligand Induces the Generation of CD20+ Plasmablasts and Plasma Cells from CD27+ Memory B-Cells

Plasma cells (PCs) have a heterogeneous phenotype in humans. While bone marrow PCs are CD20−CD138+, tonsil PCs are CD20+CD138+/− and peripheral plasmablasts (PBs) are CD20−CD138−. In vitro, PCs are mainly generated by the activation of CD27+ memory B-cells through transient stimulation of CD40, and...

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Detalhes bibliográficos
Main Authors: Geffroy-Luseau, Alexandrine, Chiron, David, Descamps, Géraldine, Jégo, Gaëtan, Amiot, Martine, Pellat-Deceunynck, Catherine
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Research Foundation 2011
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3342082/
https://ncbi.nlm.nih.gov/pubmed/22566872
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2011.00083
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