A transforming Src mutant increases the bioavailability of EGFR-ligands via stimulation of the cell surface metalloproteinase ADAM17

ADAM17 (a disintegrin and metalloproteinase 17) is a cell-surface metalloproteinase that regulates signaling via the epidermal growth factor receptor (EGFR) and has important roles in diseases such as cancer and rheumatoid arthritis. ADAM17 can be activated by stimulation of several tyrosine kinase...

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Hlavní autoři: Maretzky, Thorsten, Zhou, Wenhui, Huang, Xin-Yun, Blobel, Carl P.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3342068/
https://ncbi.nlm.nih.gov/pubmed/20871631
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2010.443
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