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The arginine finger of RasGAP helps Gln-61 align the nucleophilic water in GAP-stimulated hydrolysis of GTP

The Ras family of GTPases is a collection of molecular switches that link receptors on the plasma membrane to signaling pathways that regulate cell proliferation and differentiation. The accessory GTPase-activating proteins (GAPs) negatively regulate the cell signaling by increasing the slow intrins...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Resat, Haluk, Straatsma, T. P., Dixon, David A., Miller, John H.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2001
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC33417/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11371635/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.091506998
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