The arginine finger of RasGAP helps Gln-61 align the nucleophilic water in GAP-stimulated hydrolysis of GTP
The Ras family of GTPases is a collection of molecular switches that link receptors on the plasma membrane to signaling pathways that regulate cell proliferation and differentiation. The accessory GTPase-activating proteins (GAPs) negatively regulate the cell signaling by increasing the slow intrins...
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| I publikationen: | Proc Natl Acad Sci U S A |
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| Huvudupphov: | , , , |
| Materialtyp: | Artigo |
| Språk: | Inglês |
| Utgiven: |
National Academy of Sciences
2001
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC33417/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11371635/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.091506998 |
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