The arginine finger of RasGAP helps Gln-61 align the nucleophilic water in GAP-stimulated hydrolysis of GTP

The Ras family of GTPases is a collection of molecular switches that link receptors on the plasma membrane to signaling pathways that regulate cell proliferation and differentiation. The accessory GTPase-activating proteins (GAPs) negatively regulate the cell signaling by increasing the slow intrins...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Resat, Haluk, Straatsma, T. P., Dixon, David A., Miller, John H.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 2001
Soggetti:	Biological Sciences
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC33417/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11371635/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.091506998
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