Probing Tubulin-Blocked State of VDAC by Varying Membrane Surface Charge

Reversible blockage of the voltage-dependent anion channel (VDAC) of the mitochondrial outer membrane by dimeric tubulin is being recognized as a potent regulator of mitochondrial respiration. The tubulin-blocked state of VDAC is impermeant for ATP but only partially closed for small ions. This resi...

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Bibliografiske detaljer
Main Authors: Gurnev, Philip A., Queralt-Martin, Maria, Aguilella, Vicente M., Rostovtseva, Tatiana K., Bezrukov, Sergey M.
Format: Artigo
Sprog:Inglês
Udgivet: The Biophysical Society 2012
Fag:
Channels and Transporters
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3341544/
https://ncbi.nlm.nih.gov/pubmed/22824270
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2012.03.058
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