Gpx4 ablation in adult mice results in a lethal phenotype accompanied by neuronal loss in brain

Glutathione peroxidase 4 (Gpx4) is an antioxidant defense enzyme important in reducing hydroperoxides in membrane lipids and lipoproteins. Gpx4 is essential for survival of embryos and neonatal mice; however, whether Gpx4 is required for adult animals remains unclear. In this study, we generated a f...

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Bibliographische Detailangaben
Hauptverfasser: Yoo, Si-Eun, Chen, Liuji, Na, Ren, Liu, Yuhong, Rios, Carmen, Remmen, Holly Van, Richardson, Arlan, Ran, Qitao
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3341497/
https://ncbi.nlm.nih.gov/pubmed/22401858
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2012.02.043
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