Severe Dengue Is Associated with Consumption of von Willebrand Factor and Its Cleaving Enzyme ADAMTS-13

BACKGROUND: Thrombocytopenia, bleeding and plasma leakage are cardinal features of severe dengue. Endothelial cell activation with exocytosis of Weibel-Palade bodies (WPBs) may play an etiological role in this condition. METHODS AND PRINCIPAL FINDINGS: In a cohort of 73 Indonesian children with deng...

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Autori principali: Djamiatun, Kis, van der Ven, Andre J. A. M., de Groot, Philip G., Faradz, Sultana M. H., Hapsari, D., Dolmans, Wil M. V., Sebastian, Silvie, Fijnheer, Rob, de Mast, Quirijn
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2012
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3341341/
https://ncbi.nlm.nih.gov/pubmed/22563509
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0001628
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