The Effect of Elevated Body Mass Index on Ischemic Heart Disease Risk: Causal Estimates from a Mendelian Randomisation Approach

BACKGROUND: Adiposity, assessed as elevated body mass index (BMI), is associated with increased risk of ischemic heart disease (IHD); however, whether this is causal is unknown. We tested the hypothesis that positive observational associations between BMI and IHD are causal. METHODS AND FINDINGS: In...

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Main Authors: Nordestgaard, Børge G., Palmer, Tom M., Benn, Marianne, Zacho, Jeppe, Tybjærg-Hansen, Anne, Davey Smith, George, Timpson, Nicholas J.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2012
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3341326/
https://ncbi.nlm.nih.gov/pubmed/22563304
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pmed.1001212
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