Effects of Gut-Targeted 15-LOX-1 Transgene Expression on Colonic Tumorigenesis in Mice

Expression of 15-lipoxygenase-1 (15-LOX-1) is decreased in many human cancers; however, the mechanistic significance of its decreased expression has been difficult to determine because its mouse homolog 12/15-LOX has opposing functions. We generated a mouse model in which expression of a human 15-LO...

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Autori principali: Zuo, Xiangsheng, Peng, Zhanglong, Wu, Yuanqing, Moussalli, Micheline J., Yang, Xiu L., Wang, Yan, Parker-Thornburg, Jan, Morris, Jeffrey S., Broaddus, Russell R., Fischer, Susan M., Shureiqi, Imad
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2012
Soggetti:
Brief Communication
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3341308/
https://ncbi.nlm.nih.gov/pubmed/22472308
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jnci/djs187
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