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Chk1 suppresses bypass of mitosis and tetraploidization in p53-deficient cancer cells

Many cancer cells are unable to maintain a numerically stable chromosome complement. It is well established that aberrant cell division can generate progeny with increased ploidy, but the genetic factors required for maintenance of diploidy are not well understood. Using an isogenic model system der...

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Detalles Bibliográficos
Main Authors: Wilsker, Deborah, Chung, Jon H., Bunz, Fred
Formato: Artigo
Idioma:Inglês
Publicado: Landes Bioscience 2012
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3341228/
https://ncbi.nlm.nih.gov/pubmed/22433954
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.19944
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