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Spermine synthase overexpression in vivo does not increase susceptibility to DMBA/TPA skin carcinogenesis or Min-Apc intestinal tumorigenesis

Numerous studies have demonstrated a link between elevated polyamine biosynthesis and neoplastic growth, but the specific contribution of spermine synthase to epithelial tumor development has never been explored in vivo. Mice with widespread overexpression of spermine synthase (CAG-SpmS) exhibit dec...

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Bibliografiske detaljer
Main Authors: Welsh, Patricia A., Sass-Kuhn, Suzanne, Prakashagowda, Chethana, McCloskey, Diane E., Feith, David J.
Format: Artigo
Sprog:Inglês
Udgivet: Landes Bioscience 2012
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3341213/
https://ncbi.nlm.nih.gov/pubmed/22258329
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cbt.19241
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