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Agonist-induced conformational changes in the G-protein-coupling domain of the β(2) adrenergic receptor

The majority of extracellular physiologic signaling molecules act by stimulating GTP-binding protein (G-protein)-coupled receptors (GPCRs). To monitor directly the formation of the active state of a prototypical GPCR, we devised a method to site specifically attach fluorescein to an endogenous cyste...

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Bibliografiske detaljer
Main Authors: Ghanouni, Pejman, Steenhuis, Jacqueline J., Farrens, David L., Kobilka, Brian K.
Format: Artigo
Sprog:Inglês
Udgivet: The National Academy of Sciences 2001
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC33412/
https://ncbi.nlm.nih.gov/pubmed/11353823
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.101126198
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