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Ionizing radiation induces ATM dependent checkpoint signaling and G(2) but not G(1) cell cycle arrest in pluripotent human embryonic stem cells

Human embryonic stem (ES) cells are highly sensitive to environmental insults including DNA damaging agents, responding with high levels of apoptosis. In order to understand the response of human ES cells to DNA damage, we investigated the function of the ataxia telangiectasia mutated (ATM) DNA dama...

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Bibliografiske detaljer
Main Authors: Momčilović, Olga, Choi, Serah, Varum, Sandra, Bakkenist, Christopher, Schatten, Gerald, Navara, Christopher
Format: Artigo
Sprog:Inglês
Udgivet: 2009
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3340923/
https://ncbi.nlm.nih.gov/pubmed/19544417
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/stem.123
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