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Ellipticine increases the superhelical density of intracellular SV40 DNA by intercalation.
We investigated the in vivo effect of ellipticine, a mammalian topoisomeraseII(topoII) inhibitor, on SV40 DNA topology. In contrast to epipodophyllotoxins, ellipticine did not cause significant double stranded cleavage of intracellular SV40 DNA. Furthermore, ellipticine reduced cleavage induced by e...
Gardado en:
| Publicado en: | Nucleic Acids Res |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Oxford University Press
1992
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| Acceso en liña: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC334084/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1324474/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/20.15.4033 |
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