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Thioredoxin regulates the DNA binding activity of NF-kappa B by reduction of a disulphide bond involving cysteine 62.
A role for redox regulation in activation of the NF-kappa B transcription factor was suggested by the observation that DNA binding activity of free protein, but not preformed DNA-protein complex, is inhibited by -SH modifying agents but enhanced by reducing agents. Mutagenesis of conserved cysteine...
Sparad:
| Huvudupphovsmän: | , , , , |
|---|---|
| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
1992
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| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC334054/ https://ncbi.nlm.nih.gov/pubmed/1508666 |
| Taggar: |
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