Thioredoxin regulates the DNA binding activity of NF-kappa B by reduction of a disulphide bond involving cysteine 62.

A role for redox regulation in activation of the NF-kappa B transcription factor was suggested by the observation that DNA binding activity of free protein, but not preformed DNA-protein complex, is inhibited by -SH modifying agents but enhanced by reducing agents. Mutagenesis of conserved cysteine...

Descrición completa

Detalles Bibliográficos

Publicado en:	Nucleic Acids Res
Principais autores:	Matthews, J R, Wakasugi, N, Virelizier, J L, Yodoi, J, Hay, R T
Formato:	Artigo
Idioma:	Inglês
Publicado:	Oxford University Press 1992
Acceso en liña:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC334054/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1508666/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/20.15.3821
Tags:	Engadir etiqueta Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!