Thioredoxin regulates the DNA binding activity of NF-kappa B by reduction of a disulphide bond involving cysteine 62.

A role for redox regulation in activation of the NF-kappa B transcription factor was suggested by the observation that DNA binding activity of free protein, but not preformed DNA-protein complex, is inhibited by -SH modifying agents but enhanced by reducing agents. Mutagenesis of conserved cysteine...

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Veröffentlicht in:	Nucleic Acids Res
Hauptverfasser:	Matthews, J R, Wakasugi, N, Virelizier, J L, Yodoi, J, Hay, R T
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Oxford University Press 1992
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC334054/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1508666/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/20.15.3821
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