The Influence of Spin-Labeled Fluorene Compounds on the Assembly and Toxicity of the Aβ Peptide

BACKGROUND: The deposition and oligomerization of amyloid β (Aβ) peptide plays a key role in the pathogenesis of Alzheimer's disease (AD). Aβ peptide arises from cleavage of the membrane-associated domain of the amyloid precursor protein (APP) by β and γ secretases. Several lines of evidence po...

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Détails bibliographiques
Auteurs principaux: Petrlova, Jitka, Kálai, Tamás, Maezawa, Izumi, Altman, Robin, Harishchandra, Ghimire, Hong, Hyun-Seok, Bricarello, Daniel A., Parikh, Atul N., Lorigan, Gary A., Jin, Lee-Way, Hideg, Kálmán, Voss, John C.
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2012
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3340382/
https://ncbi.nlm.nih.gov/pubmed/22558151
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0035443
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