Synthesis and functional survey of new Tacrine analogs modified with nitroxides or their precursors

A series of new Tacrine analogs modified with nitroxides or pre-nitroxides on 9-amino group via methylene or piperazine spacers were synthesized; the nitroxide or its precursors were incorporated into the Tacrine scaffold. The new compounds were tested for their hydroxyl radical and peroxyl radical...

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Detalhes bibliográficos
Main Authors: Kálai, Tamás, Altman, Robin, Maezawa, Izumi, Balog, Mária, Morisseau, Christophe, Petrlova, Jitka, Hammock, Bruce D., Jin, Lee-Way, Trudell, James, Voss, John C., Hideg, Kálmán
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4065883/
https://ncbi.nlm.nih.gov/pubmed/24657571
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2014.03.026
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