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RAB-7 Antagonizes LET-23 EGFR Signaling during Vulva Development in Caenorhabditis elegans

The Rab7 GTPase regulates late endosome trafficking of the Epidermal Growth Factor Receptor (EGFR) to the lysosome for degradation. However, less is known about how Rab7 activity, functioning late in the endocytic pathway, affects EGFR signaling. Here we used Caenorhabditis elegans vulva cell fate i...

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Detalhes bibliográficos
Main Authors: Skorobogata, Olga, Rocheleau, Christian E.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3340361/
https://ncbi.nlm.nih.gov/pubmed/22558469
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0036489
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