Exploring the Dynamic Range of the Kinetic Exclusion Assay in Characterizing Antigen-Antibody Interactions

Therapeutic antibodies are often engineered or selected to have high on-target binding affinities that can be challenging to determine precisely by most biophysical methods. Here, we explore the dynamic range of the kinetic exclusion assay (KinExA) by exploiting the interactions of an anti-DKK antib...

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Detalhes bibliográficos
Main Authors: Bee, Christine, Abdiche, Yasmina N., Stone, Donna M., Collier, Sierra, Lindquist, Kevin C., Pinkerton, Alanna C., Pons, Jaume, Rajpal, Arvind
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3340344/
https://ncbi.nlm.nih.gov/pubmed/22558410
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0036261
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