Deregulated Hepatic Metabolism Exacerbates Impaired Testosterone Production in Mrp4-deficient Mice

The physiological role of multidrug resistance protein 4 (Mrp4, Abcc4) in the testes is unknown. We found that Mrp4 is expressed primarily in mouse and human Leydig cells; however, there is no current evidence that Mrp4 regulates testosterone production. We investigated its role in Leydig cells, whe...

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Main Authors: Morgan, Jessica A., Cheepala, Satish B., Wang, Yao, Neale, Geoff, Adachi, Masashi, Nachagari, Deepa, Leggas, Mark, Zhao, Wenchen, Boyd, Kelli, Venkataramanan, Raman, Schuetz, John D.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2012
Teme:
Cell Biology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3340271/
https://ncbi.nlm.nih.gov/pubmed/22375007
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.319681
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