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Mrp4 Confers Resistance to Topotecan and Protects the Brain from Chemotherapy
The role of the multidrug resistance protein MRP4/ABCC4 in vivo remains undefined. To explore this role, we generated Mrp4-deficient mice. Unexpectedly, these mice showed enhanced accumulation of the anticancer agent topotecan in brain tissue and cerebrospinal fluid (CSF). Further studies demonstrat...
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| Autors principals: | , , , , , , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Society for Microbiology
2004
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC506999/ https://ncbi.nlm.nih.gov/pubmed/15314169 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.24.17.7612-7621.2004 |
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