Mrp4 Confers Resistance to Topotecan and Protects the Brain from Chemotherapy

The role of the multidrug resistance protein MRP4/ABCC4 in vivo remains undefined. To explore this role, we generated Mrp4-deficient mice. Unexpectedly, these mice showed enhanced accumulation of the anticancer agent topotecan in brain tissue and cerebrospinal fluid (CSF). Further studies demonstrat...

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Detalhes bibliográficos
Main Authors: Leggas, Markos, Adachi, Masashi, Scheffer, George L., Sun, Daxi, Wielinga, Peter, Du, Guoqing, Mercer, Kelly E., Zhuang, Yanli, Panetta, John C., Johnston, Brad, Scheper, Rik J., Stewart, Clinton F., Schuetz, John D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2004
Assuntos:
Mammalian Genetic Models with Minimal or Complex Phenotypes
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC506999/
https://ncbi.nlm.nih.gov/pubmed/15314169
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.24.17.7612-7621.2004
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