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Structural Characterization of Streptococcus pneumoniae Serotype 9A Capsule Polysaccharide Reveals Role of Glycosyl 6-O-Acetyltransferase wcjE in Serotype 9V Capsule Biosynthesis and Immunogenicity

The putative capsule O-acetyltransferase gene wcjE is highly conserved across various Streptococcus pneumoniae serotypes, but the role of the gene in capsule biosynthesis and bacterial fitness remains largely unclear. Isolates expressing pneumococcal serotype 9A arise from precursors expressing wcjE...

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Main Authors: Calix, Juan J., Saad, Jamil S., Brady, Allison M., Nahm, Moon H.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2012
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3340191/
https://ncbi.nlm.nih.gov/pubmed/22367197
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.346924
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