Analysis of Binding Sites on Complement Factor I Using Artificial N-Linked Glycosylation

Factor I (FI) is a serine protease that inhibits all complement pathways by degrading activated complement components C3b and C4b. FI functions only in the presence of several cofactors, such as factor H, C4b-binding protein, complement receptor 1, and membrane cofactor protein. FI is composed of tw...

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Bibliographic Details
Main Authors: Sanchez-Gallego, Jose I., Groeneveld, Tom W. L., Krentz, Stefanie, Nilsson, Sara C., Villoutreix, Bruno O., Blom, Anna M.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2012
Subjects:
Immunology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3340171/
https://ncbi.nlm.nih.gov/pubmed/22393059
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.326298
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