T Cell Receptors are Structures Capable of Initiating Signaling in the Absence of Large Conformational Rearrangements

Native and non-native ligands of the T cell receptor (TCR), including antibodies, have been proposed to induce signaling in T cells via intra- or intersubunit conformational rearrangements within the extracellular regions of TCR complexes. We have investigated whether any signatures can be found for...

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Hauptverfasser: Fernandes, Ricardo A., Shore, David A., Vuong, Mai T., Yu, Chao, Zhu, Xueyong, Pereira-Lopes, Selma, Brouwer, Heather, Fennelly, Janet A., Jessup, Claire M., Evans, Edward J., Wilson, Ian A., Davis, Simon J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2012
Schlagworte:
Immunology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3339974/
https://ncbi.nlm.nih.gov/pubmed/22262845
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.332783
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