Interferon Regulatory Factor 1 Transactivates Expression of Human DNA Polymerase η in Response to Carcinogen N-Methyl-N′-nitro-N-nitrosoguanidine

DNA polymerase η (Polη) implements translesion DNA synthesis but has low fidelity in replication. We have previously shown that Polη plays an important role in the genesis of nontargeted mutations at undamaged DNA sites in cells exposed to the carcinogen N-methyl-N′-nitro-N-nitrosoguanidine (MNNG)....

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Bibliografiske detaljer
Main Authors: Qi, Hongyan, Zhu, Huifang, Lou, Meng, Fan, Yanfeng, Liu, Hong, Shen, Jing, Li, Zhongjie, Lv, Xue, Shan, Jianzhen, Zhu, Lijun, Chin, Y. Eugene, Shao, Jimin
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2012
Fag:
Molecular Bases of Disease
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3339973/
https://ncbi.nlm.nih.gov/pubmed/22367195
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.313429
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