Interferon Regulatory Factor 1 Transactivates Expression of Human DNA Polymerase η in Response to Carcinogen N-Methyl-N′-nitro-N-nitrosoguanidine

DNA polymerase η (Polη) implements translesion DNA synthesis but has low fidelity in replication. We have previously shown that Polη plays an important role in the genesis of nontargeted mutations at undamaged DNA sites in cells exposed to the carcinogen N-methyl-N′-nitro-N-nitrosoguanidine (MNNG)....

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Detalhes bibliográficos
Main Authors: Qi, Hongyan, Zhu, Huifang, Lou, Meng, Fan, Yanfeng, Liu, Hong, Shen, Jing, Li, Zhongjie, Lv, Xue, Shan, Jianzhen, Zhu, Lijun, Chin, Y. Eugene, Shao, Jimin
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Molecular Bases of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3339973/
https://ncbi.nlm.nih.gov/pubmed/22367195
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.313429
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