Human Anti-prion Antibodies Block Prion Peptide Fibril Formation and Neurotoxicity

Prion diseases are a group of rare, fatal neurodegenerative disorders associated with a conformational transformation of the cellular prion protein (PrP(C)) into a self-replicating and proteinase K-resistant conformer, termed scrapie PrP (PrP(Sc)). Aggregates of PrP(Sc) deposited around neurons lead...

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Autors principals: Wei, Xing, Roettger, Yvonne, Tan, Bailin, He, Yongzheng, Dodel, Richard, Hampel, Harald, Wei, Gang, Haney, Jillian, Gu, Huiying, Johnstone, Brian H., Liu, Junyi, Farlow, Martin R., Du, Yansheng
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2012
Matèries:
Neurobiology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3339962/
https://ncbi.nlm.nih.gov/pubmed/22362783
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.255836
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