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Sequence-dependent Prion Protein Misfolding and Neurotoxicity
Prion diseases are neurodegenerative disorders caused by misfolding of the normal prion protein (PrP) into a pathogenic “scrapie” conformation. To better understand the cellular and molecular mechanisms that govern the conformational changes (conversion) of PrP, we compared the dynamics of PrP from...
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| Auteurs principaux: | , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
American Society for Biochemistry and Molecular Biology
2010
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2978619/ https://ncbi.nlm.nih.gov/pubmed/20817727 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.174391 |
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