Steroid Receptor Coactivator-interacting Protein (SIP) Inhibits Caspase-independent Apoptosis by Preventing Apoptosis-inducing Factor (AIF) from Being Released from Mitochondria

Apoptosis-inducing factor (AIF) is a caspase-independent death effector. Normally residing in the mitochondrial intermembrane space, AIF is released and translocated to the nucleus in response to proapoptotic stimuli. Nuclear AIF binds to DNA and induces chromatin condensation and DNA fragmentation,...

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Bibliografiske detaljer
Main Authors: Wang, Dandan, Liang, Jing, Zhang, Yu, Gui, Bin, Wang, Feng, Yi, Xia, Sun, Luyang, Yao, Zhi, Shang, Yongfeng
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2012
Fag:
Cell Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3339961/
https://ncbi.nlm.nih.gov/pubmed/22371500
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.334151
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