Involvement of VDAC, Bax and Ceramides in the Efflux of AIF from Mitochondria during Curcumin-Induced Apoptosis

BACKGROUND: We previously identified curcumin as a potent inducer of fibroblast apoptosis, which could be used to treat hypertrophic scar formation. Here we investigated the underlying mechanism of this process. PRINCIPAL FINDINGS: Curcumin-induced apoptosis could not be blocked by caspase-inhibitor...

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Bibliografiske detaljer
Main Authors: Scharstuhl, Alwin, Mutsaers, Henricus A. M., Pennings, Sebastiaan W. C., Russel, Frans G. M., Wagener, Frank A. D. T. G.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2009
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2725322/
https://ncbi.nlm.nih.gov/pubmed/19693275
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0006688
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